Synthetic Route of 1132-95-2,Some common heterocyclic compound, 1132-95-2, name is 1,1-Diisopropoxycyclohexane, molecular formula is C12H24O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The product from (1) was dissolved in 310 mL of acetone. 127,5 g of 1,1- diisopropoxycyclohexane and 31.0 g of pyridine hydrobromide were added. The mixture was stirred at 40-45 C for 3 hours. Then 300 mL of isopropyl acetate, 250 mL of 5% aqueous sodium carbonate and 9 mL of 20% aqueous sodium hydroxide were added. After stirring the aqueous phase was seperated off, and the organic phase was concentrated by distilling under vacuum. 246 g of a mixture 2′, 4″-0- bis (trimethylsilyl) erythromycin A 9- {O- [1- (1- methylethoxy)-cyclohexyl] oxime} and isopropyl acetate was obtained.; (2) The product obtained above in (1) was dissolved in 310 mL of acetone. 127,5 g of 1,1- diisopropoxycyclohexane and 31.0 g of pyridine hydrobromide were then added. The mixture was stirred at 40-45 C for 3 hours. Then 300 mL of isopropyl acetate, 250 mL of 5% aqueous sodium carbonate and 9 mL of 20% aqueous sodium hydroxide were added. After stirring and the aqueous phase was seperated off, and the organic phase was concentrated by distilling under vacuum. 236 g of a mixture 2′, 4″-0- bis (trimethylsilyl) erythromycin A 9- {O- [1- (1-methylethoxy)-cyclohexyl] oxime} and isopropyl acetate was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1-Diisopropoxycyclohexane, its application will become more common.
Reference:
Patent; SANDOZ AG; WO2005/90377; (2005); A1;,
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