Related Products of 619-42-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 619-42-1 name is Methyl 4-bromobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a sealed vial was added aniline (1.2 eq), methyl 4-(phenylamino)benzoate (1 eq), Pd(OAc)2 (0.05mmol), rac-BINAP (0.05 eq), K2CO3 (3 eq) and toluene. Then the sealed vial was irradiated in the microwave at 130C for 2h. After the reaction completed, ethyl acetate was added to dilute the reaction mixture, and then filtered by diatomite. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel to afford diphenylamine intermediate (8).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-bromobenzoate, and friends who are interested can also refer to it.
Reference:
Article; Huang, Yafei; Yu, Mingcheng; Sun, Nannan; Tang, Ting; Yu, Fazhi; Song, Xiaoxia; Xie, Qiong; Fu, Wei; Shao, Liming; Wang, Yonghui; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 465 – 476;,
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