Application of 555-43-1,Some common heterocyclic compound, 555-43-1, name is Propane-1,2,3-triyl tristearate, molecular formula is C57H110O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Alcoholysis of triglycerides Alcoholysis of pure triglycerides (TGs), including trilaurin, tripalmitin and tristearin, was carried out. Most diglyceride (DG) obtained from alcoholysis reaction were 1,2-DG. A high amount OF uNREACTED TG remained in the reaction mixture. Acyl migration was observed during the reaction, especially in hydrolysis reaction, as illustrated in Figure 18. Figure 18 shows data from alcoholysis reaction showing the 1,3- DS/1, 2-DS ratio during alcoholysis and hydrolysis of tristearin. DEP = D-EP100, RM = Lipozyme RM IM, Hx = n-hexane, HYD = hydrolysis, ALC = alcoholysis. The reaction catalyzed by Lipozyme RM IMTM, though gave lower yield, showed higher acyl migration than the reaction catalyzed by D-EP100. Low acyl migration was observed in alcoholysis using CAL-B after 6h. This could be because 1,2- DG and 1,3-DG were produced at the same time according to the non-specificity of CAL- B. D-EP 100 showed higher activity than CAL-B and Lipozyme RM, respectively, in alcoholysis of tripalmitin and tristearin. Effect OF AW : HIGHER yield and less MG was obtained from alcoholysis at aW 0.11 than 0.43. It was found that MG was increased with increasing aw. Effect of solvents (on yield and acyl migration): Highest yield was obtained with MTBE. Alcoholysis in n-hexane and isooctane gave moderate yield, while acetone was a poor solvent for Lipozyme RM. The reaction performed in n- hexane showed faster acyl migration than in MTBE, as illustrated in Figures 18 and 19. Figure 19 illustrates data from the hydrolysis of trilaurin at 60C by Lipozyme RM IM (DG = dilaurin).
The synthetic route of 555-43-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DIVERSA CORPORATION; WO2005/32496; (2005); A2;,
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