Reference of 37746-78-4,Some common heterocyclic compound, 37746-78-4, name is (E)-Ethyl 4-bromobut-2-enoate, molecular formula is C6H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 1-(1H-pyrrol-2-yl) ethanone 1 (109 mg, 1.0 mmol), (E)-ethyl 4-bromobut-2-enoate 2 (256 mg, 1.0 mmol), and K2CO3 (414 mg, 3.0 mmol) in CH3CN (5 mL)was refluxed. The end of the reaction was monitored by the TLC. Ice water(100 mL) was poured into the mixture and CH2Cl2 (3 30 mL) was used toextract the mixture. The combined organic layers were dried over Na2SO4,filtered, and concentrated in vacuo. Purification by flash columnchromatography (Hexane/EtOAc = 10:1, v/v) afforded the desired product 7
The synthetic route of 37746-78-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Bingchuan; Huang, Zixiao; Guan, Hegen; Niu, Xiaoyi; Li, Yanqiu; Fang, Shuai; Ma, Chen; Tetrahedron Letters; vol. 54; 45; (2013); p. 5994 – 5997;,
Ester – Wikipedia,
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