In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141-12-8 as follows. Product Details of 141-12-8
6.983g (0.035mol) of 1a was added to a stirring solution of 0.491g (3.5mmol) of salicylic acid, 0.665g (3.5mmol) of SeO2 and 14.82g (0.164mol) of tert-butylhydroperoxide (70%) in 35mL of diethyl ether at 0C and left to stir for 48h. The volume of the mixture was then reduced to one half and was washed with 15mL of 5% NaHCO3, saturated CuSO4, repeatedly washed with saturated Na2S2O3, water, brine and then dried over MgSO4. Solvent was removed by rotary evaporation and the crude oil was then purified by flash chromatography (5% EtOAc/hexanes) to afford 3.53g (47%) of 2a. TLC: (Rf 0.7). 1H NMR (300MHz): delta 9.28 (s, 1H), 6.37 (t, 1H), 5.32 (t, 1H), 4.49 (d, 2H), 2.39 (q, 2H), 2.25 (t, 2H), 1.91 (s, 3H) 1.69 (s, 3H), 1.58 (s, 3H). 13C NMR (76MHz): delta 195.2, 171.0, 153.2, 140.8, 139.7, 120.5, 60.7, 30.4, 27.3, 25.8 (contaminant), 23.2, 21.0, 9.2.
According to the analysis of related databases, 141-12-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Mostafavi, Anahita Z.; Lujan, Donovan K.; Erickson, Katelyn M.; Martinez, Christina D.; Troutman, Jerry M.; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5428 – 5435;,
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