Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 680-65-9, name is Diethyl difluoromalonate, A new synthetic method of this compound is introduced below., SDS of cas: 680-65-9
Diethyl difluoropropanedioate (2.87 ml, 17.23 mmol) was dissolved in MeOH (20 mL) and a solution of 2,3-dihvdro-1H-inden-2-ainine (2.07 g, 15.51 mmol) in MeOH (15mL) was added dropwise. The reaction was stirred at RT for 14 h. The reaction wasconcentrated and purified by Biotage FCC (50 g SNAP KP-Si02, 0-50% EtOAc in Heptanes)affording the title compound as a pale brown solid (1.79 g, 91% purity, 35%)?H NMR (500 MHz, DMSO-d6) 9.48 (d, J = 6.9 Hz, 1H), 7.22 (dcl, J = 5.3, 3.4 Hz,2H), 7.15 (dd, J = 5.5, 3.2 Hz, 2H), 4.60-4.48 (in, IH). 3.88 (s, 3H), 3.20 (dd, .J= 15.9, 7.9Hz, 2H), 2.91 (dd, J= 15.9, 6.6 Hz, 2H). LCMS Method C: rt 1.09 mm, 91%, m/z 269.95(MW)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; EVOTEC INTERNATIONAL GMBH; GAMPE, Christian, M.; KAHNE, Daniel, Evan; KAHNE, Suzanne, Walker; QIAO, Yuan; EAST, Stephen; PARKES, Alastair, L.; SOUTHEY, Michelle; HUNTER, James; WHITTAKER, Mark; ARTHUIS, Martin; (359 pag.)WO2016/191658; (2016); A1;,
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