Adding a certain compound to certain chemical reactions, such as: 106614-28-2, name is Methyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106614-28-2, Product Details of 106614-28-2
To a solution of methyl 2, 4-difluorobenzoate (3.44 g, 20.00 mmol) in DMF (50 mL) was added 1H-pyrrolo [2, 3-b] pyridin-5-ol (2.70 g, 20.00 mmol) and K 2CO 3 (5.6 g, 40.00 mmol), the mixture was stirred at 80C for 20h. Cooled to room temperature, partitioned between EA (40 ml) and H 2O (40 mL), the aqueous layer was extracted with EA (20 mL). The combined organic layers were washed with H 2O (30 mL3), concentrated and purified by CombiFlash (0-60%, EA/PE) to give the crude product, which was crystallized from EA/PE=1/1 (50 mL) to give the isomer. The mother liquid was left standing over night, the precipitate was collected by filtration to give methyl 2- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy) -4-fluorobenzoate (600 mg) as a white solid. [M+1] + 286.9.
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Reference:
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
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