Application of 5335-05-7, A common heterocyclic compound, 5335-05-7, name is Chloromethyl benzoate, molecular formula is C8H7ClO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(Step 2) Iodomethyl benzoate (0277) (0278) Chloromethyl benzoate (10.0 g, 58.8 mmol) was dissolved in acetonitrile (70.0 ml), sodium iodide (17.6 g, 117 mmol) was added thereto, and the resulting mixture was stirred at room temperature for 24 hours. Acetonitrile was distilled off under reduced pressure, and diethyl ether was added. The precipitated solid was filtered off, washed with diethyl ether, and dried under reduced pressure, and then purified by silica gel column chromatography (petroleum ether:ethyl acetate=30:1 to 10:1) to obtain the title compound (14.5 g, 94%). (0279) 1H NMR (CDCl3, 400 MHz): delta 8.06-8.04 (m, 2H), 7.64-7.62 (m, 1H), 7.49-7.44 (m, 2H), 6.17 (s, 2H)
The synthetic route of 5335-05-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ajinomoto Co., Inc.; UENO, Hirokazu; YAMAMOTO, Takashi; MIYAZAWA, Tomoko; SHINKAI, Kenji; ARISAKA, Harumi; TAKANOHASHI, Toshiyuki; (122 pag.)US2016/244451; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics