Sources of common compounds: 2318-25-4

Reference of 2318-25-4, These common heterocyclic compound, 2318-25-4, name is Ethyl 3-ethoxy-3-iminopropionate hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 3C; Preparation of 2-ethoxy-8-thiomethyl-4-hydroxyquinoline (3C4); Step A; The imidate salt 3A2 (1.4 g, 7.2 mmol, 1 eq.) was combined with 2-(methylthio)aniline EPO 3C1 (0.96 g, 7.50 mmol, 1 eq.) in ethanol (15 ml.) under an N2 atmosphere. The reaction mixture was stirred at RT. (1 h) and monitored by HPLC. The reaction mixture was concentrated and then ether was added and the mixture filtered. The solids were washed with ether and the combined ether washes concentrated in vacuo. The resulting adduct 3C2 was obtained as a yellow oil (1.66 g, 82percent) and used as is in the next step. MS electrospray: (M + H)+; 282 and (M – H)”; 280.

Statistics shows that Ethyl 3-ethoxy-3-iminopropionate hydrochloride is playing an increasingly important role. we look forward to future research findings about 2318-25-4.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2007/9227; (2007); A1;,
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