Related Products of 18595-12-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18595-12-5 name is Methyl 5-amino-2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of THF (5 mL) containing compound 3 (350 mg, 1.03 mmol) were added sequentially, HOBT (224 mg,1.6 mmol), EDC.HCl (306 mg, 1.6 mmol), TEA (0.28 mL, 2.0 mmol) and methyl 5-amino-2-methylbenzoate (3a) (198 mg, 1.2 mmol). The resulting mixture was stirred at room temperature for 12 h. The reaction mixture was diluted with dichloromethane (10 mL) followed by water (15 mL), the organic layer was separated, washed with water (2 ¡Á 15 mL) followed by brine solution to obtain the crude compound 4. The crude compound was purified by column chromatography using 60-120 silica gel and eluted with 30 % EtOAc/hexane to afford compound 4. Pale white solid; Yield: 280 mg, 66 %; m.p.: 160-162 C; IR (neat, numax): 3431, 2925, 2858, 1620,1442, 1255, 1219, 1170, 1079, 954; 1H NMR: (CDCl3, 400 MHz): delta 7.96 (br.s, 1H-NH), 7.66 (d, J = 6.4 Hz, 1H), 7.46 (t, J = 7.2 Hz, 1H), 7.34 (d, J = 7.6Hz, 1H), 7.22 – 7.33 (d, 4 H),4.68 (br.p, 1H), 3.90 (s, 3H), 3.8(t,1H),3.06 (br.t, 2H) 2.55 (s,3 H)2.47(q, 1H) 1.87-2.03 (m, 4 H). ESI MS: m/z (rel. abund.%): 465.37 (M+,100).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-amino-2-methylbenzoate, and friends who are interested can also refer to it.
Reference:
Article; Reddy; Prasad; Venkataramana; Asian Journal of Chemistry; vol. 28; 1; (2016); p. 138 – 142;,
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