Related Products of 25662-28-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25662-28-6, name is Methyl 1-cyclopentene-1-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Under nitrogen atmosphere, a mixture of in H2O (0.90muL, 0.050mmol) in THF (1mL) was added to an oven-dried reaction tube charged with (R)-H8-BINOL (22.1mg, 0.075mmol). After stirred at RT for 5min, Bu2Mg (1.0M in heptane, 50.0muL, 0.050mmol) and diarylphosphine oxide (3, 0.50mmol, 0.5M in anhydrous THF) were sequentially added and stirred for another 5min before being cooled to-20C. alpha,beta-Unsaturated ester (2, 0.50mmol) was then added, and the reaction was stirred at-20C for 2-3 days. The reaction mixture was quenched with sat. NH4Cl (2mL), diluted with H2O (5mL) and extracted with CH2Cl2 (10mL¡Á2). The combined organic phase was dried over anhydrous Na2SO4. After filtration and concentration, and the residue was purified by silica gel column chromatography (hexane: THF=5:1 to 1:1) to give the corresponding product. The enantiomeric excess was determined by the chiral HPLC analysis.
The synthetic route of Methyl 1-cyclopentene-1-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Cao, Meng-Yue; Xu, Zhi-Min; Gao, Wei; Liu, Juan; Tan, Fen; Lu, Hai-Hua; Tetrahedron; vol. 75; 24; (2019); p. 3282 – 3291;,
Ester – Wikipedia,
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