Electric Literature of 18013-97-3, A common heterocyclic compound, 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, molecular formula is C12H12Br2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
60 g (160 mmol) of diethyl dibromoterephthalate, 43 g (320 mmol) of o-tolylboronic acid, 365 mg (0.32 mmol) of Pd(PPh3)4 and 92 g (660 mmol) of K2CO3 are heated at the boil for 4 h in 300 ml of toluene and 300 ml of water. The mixture is subsequently partitioned between toluene and water, and the organic phase is washed three times with water and dried over Na2SO4. The residue remaining is recrystallised twice from heptane to give colourless crystals. The yield is 51 g (127 mmol, 81%).
The synthetic route of 18013-97-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Patent GmbH; US2011/92701; (2011); A1;,
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