Application of 927-68-4, These common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of Intermediate 11 (470 mg, 1.50 mmol), 2-bromoethyl acetate (1.00 g, 5.99 mmol) and DBU (913 mg, 6.01 mmol) in DMF (3 ml) was heated under argon at 80QC for 1.5 h. On cooling the reaction mixture was diluted with EtOAc (50 ml) and 1M aqueous HCI (50 ml). The organic layer was separated, washed with water (40 ml) and brine (40 ml), dried (Na2SO4) and evaporated. The crude product was chromatographed on an Isolute Si Il cartridge (20 g) eluting with 50-100% EtOAc in pentane.Yield: 457 mg (63%)LC-MS (Method 1): Rt 3.22 min, m/z 486 [MH+]
Statistics shows that 2-Bromoethyl acetate is playing an increasingly important role. we look forward to future research findings about 927-68-4.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2007/107706; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics