Reference of 82782-85-2, The chemical industry reduces the impact on the environment during synthesis 82782-85-2, name is Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, I believe this compound will play a more active role in future production and life.
General procedure: A solution of pyrrole 1 (0.20 g, 1.10 mmol) in anhydrous THF (2 ml) was added to a stirred suspension of NaH (55.0 mg, 2.29 mmol) (pre-rinsed with anhydrous hexane from a 55% dispersion in mineral oil) in anhydrous THF (10 ml) under an argon atmosphere, and the mixture was stirred for 30 min. Then a solution of iodomethane (0.14 ml, 2.19 mmol) in THF (5 ml) was added dropwise, and the mixture was stirred at 40C until the starting pyrrole was consumed (TLC control). The mixture was cooled and quenched with saturated NH4Cl solution, the product was extracted with CH2Cl2 (3¡Á20 ml). The solvent was evaporated, the residue was purified by column chromatography on SiO2 (light petroleum-ethylacetate, 5:1) to give 0.17 g (79%) of compound 2a as slightly yellow crystals, mp 62-63C. IR (nu/cm-1): 1710, 1695, 1532, 1464, 1445, 1378,1369, 1235, 1209, 1179, 1095, 1075, 962, 728. 1H NMR (500 MHz,CDCl3) delta: 3.86 (s, 3H, OMe), 4.06 (s, 3H, NMe), 6.95 (d, 1H, H-3,J 5.4 Hz), 7.18 (s, 1H, H-6), 7.34 (d, 1H, H-2, J 5.4 Hz). 13C NMR(125 MHz, CDCl3) delta: 51.3 (NMe, OMe), 109.0 (C6), 110.0 (C3), 114.8(C6a), 121.9 (C5), 129.13 (C2), 138.0 (C3a), 164.6 (CO2Me).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Torosyan, Seda A.; Zagitov, Vadim V.; Gimalova, Fanuza A.; Biglova, Raisa Z.; Miftakhov, Mansur S.; Mendeleev Communications; vol. 28; 2; (2018); p. 192 – 194;,
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