Electric Literature of 706791-83-5,Some common heterocyclic compound, 706791-83-5, name is Methyl 3-amino-5-bromobenzoate, molecular formula is C8H8BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
TEA (0.909 ml_, 6.52 mmol) was added to a mixture of propionic acid (0.21 1 ml_, 2.83 mmol) and HATU (1 .157 g, 3.04 mmol) in DMF (1 .0 ml_). After 20 min, methyl 3-amino-5- bromobenzoate (CAS 706791 -83-5) (0.5 g, 2.173 mmol) was added and the resulting mixture was stirred at room temperature for 18 h. The reaction was diluted with EtOAc and water. The aqueous phase was extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2S04, filtered and concentrated. The crude material was purified by flash column chromatography on silica gel (heptane/EtOAc = 100:0 to 0: 100) to give the title compound. 1 H NMR (400 MHz, CHLOROFORM-c/) delta ppm 8.20 (s, 1 H), 7.91 (app. d, J=2.0 Hz, 2 H), 7.15 (br. s. , 1 H), 3.93 (s, 3 H), 2.42 (q, J=7.5 Hz, 2 H), 1 .27 (t, J=7.6 Hz, 3 H).
The synthetic route of 706791-83-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BELANGER, David B.; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; KARKI, Rajeshri Ganesh; MAINOLFI, Nello; POWERS, James J.; RANDL, Stefan Andreas; ROGEL, Olivier; VULPETTI, Anna; YOON, Taeyoung; WO2015/9977; (2015); A1;,
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