Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4934-99-0, name is Methyl 3-hydroxycyclobutanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H10O3
10450] Step 1: To a nitrogen flushed vessel containing NaR (82 mg, 3.4 mmol), THF (6 mE) was added followed by the dropwise addition of methyl 3-hydroxycyclobutanecarboxy- late (0.360 mE, 3.4 mmol). The resulting suspension was allowed to stir at 0 C. for 35 mm. and then at RT for 45 mm. In a separate round bottom flask flushed with nitrogen, diisopropylamine (0.5 60 mE, 4 mmol) in THF (5 mE) was cooled to -78 C. before n-l3uEi (2.0 M in hexanes, 2 mE, 4 mmol) was added dropwise over 5 mm. The resulting solution wasallowed to stir at -78 C. for 30 mm. and then at 0 C. for 30 mm. The EDA thus generated was then added dropwise to the sodium alkoxide suspension at -78 C. Finally, ethyl iodide (0.320 mE, 4 mmol) was added and stirred at 0 C. for 15 mm and then at RT for 2.5 h. The crude mixture was quenched with sat. NH4C1 and extracted in ether. The combined organics were then washed further with brine, dried over Na2504, filtered and the filtrate concentrated in vacuo. Purification by way of column chromatography (5i02, 0-50% EtOAc/hexanes) afforded methyl 1 -ethyl-3-hydroxycyclobutanecar- boxylate. (277 mg, 51% yield).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4934-99-0.
Reference:
Patent; NOVIRA THERAPEUTICS, INC.; Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; (76 pag.)US2016/151375; (2016); A1;,
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