Adding a certain compound to certain chemical reactions, such as: 32122-09-1, name is Ethyl 2-(benzyloxy)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32122-09-1, HPLC of Formula: C11H14O3
Preparation of Intermediate G-1. 10081] To a stirred solution of A-i (60 g, 309 mmol, 1 eq) and 1 -methylimidazole (30.4 g, 370 mmol, 1.2 eq) in CH2C12 (1 E) was added acetyl chloride (24.3 g, 309 mmol, 1 eq) at-45 C. under N2. After stirring for 20 mi TiC14 (210 g, 1.08 mol, 3.5 eq) and tributylamine (230 g, 1.24 mol, 4 eq) were added to the mixture at -45C. under N2, and continues to stir for 50 minutes at -45 C. under N2. Afier completion, water and ethyl acetate were added. The organic layer was separated and the aqueous layer was extracted with ethyl acetate twice. The organic layer was washed with brine and dried over sodium sulfate. The solids were removed by filtration and the solvents of the filtrate were removed under reduced pressure. The crude was purified via silica column chromatography using a heptane to ethyl acetate gradient to afford a pale yellow oil, G-i.10082] ?H NMR (400 MHz, CHEOROFORM-d) oe ppm1.30 (t, J=7.2 Hz, 3H), 2.28 (s, 3H), 4.27 (q, J=7.2 Hz, 2H),4.41 (s, 1H), 4.58 (d, J=ii.8 Hz, 1H), 4.75 (d, J=i 1.8 Hz, 1H),7.32-7.43 (m, 5H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(benzyloxy)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; McGowan, David; Raboisson, Pierr Jeane-Marie Bernar; Embrechts, Werner; Jonckers, Tim Hugo Maria; Last, Stefaan Julien; Pieters, Serge Maria Aloysius; Vlach, Jaromir; US2014/45849; (2014); A1;,
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