Adding a certain compound to certain chemical reactions, such as: 383-62-0, name is Ethyl 2-chloro-2,2-difluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 383-62-0, COA of Formula: C4H5ClF2O2
EXAMPLE 174(R)-5-(5-(Difluoromethoxy)pyrimidin-2-yloxy)-N-(4-(morpholin-2-yl)phenyl)pyrimidin-2-aminea) 2-Chloro-5-(5-(difluoromethoxy)pyrimidin-2-yloxy)pyrimidine2-Chloropyrimidin-5-ol (0.5 g) was combined with DMF (5 ml) to give a colourless solution. K2CO3 (582 mg) and ethyl 2-chloro-2,2-difluoroacetate (534 mul) were then added. The reaction mixture was stirred at 70 C. overnight to afford a brown suspension. The reaction mixture was then poured into EtOAc and washed sequentially with water and with saturated brine. The organic layer was separated, dried over Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel; gradient: 0% to 60% EtOAc in hexanes) to afford 2-chloro-5-(5-(difluoromethoxy)pyrimidin-2-yloxy)pyrimidine (154 mg, 15%) as a yellow solid. MS (ISP): 277.0 ([{37Cl}M+H]+), 275.0 ([{35Cl}M+H]+).
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Reference:
Patent; Galley, Guido; Norcross, Roger; Pflieger, Philippe; US2012/245172; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics