Synthetic Route of 21597-54-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21597-54-6, name is Methyl 3-amino-2-naphthoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Synthesis of Intermediate (C) (0258) 15 g (74.5 mmol) of Intermediate (B) was added to 200 mL of tetrahydrofuran (THF). Then, while slowly stirring the resulting mixture, 5.72 g (149 mmol) of NaH (60% dispersion in mineral oil) was added dropwise thereto. The obtained reaction mixture was refluxed at a temperature of about 60 C. for about 72 hours, cooled to room temperature, and 250 mL of distilled water was added thereto to complete the reaction. 500 mL of 2N HCl was slowly added to the resulting reaction mixture, followed by stirred for about 60 minutes. The formed solid product was subjected to filtration and washed using distilled water. The formed solid product was vacuum-dried, thereby obtaining 8.07 g of Intermediate (C) (yield: 64%). 1H NMR (300 MHz, DMSO-d6): 10.5 (s, 2H), 7.92 (m, 4H), 7.88 (m, 4H), 7.64 (s, 2H), 7.46 (s, 2H).
The synthetic route of Methyl 3-amino-2-naphthoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY; Kim, Mikyung; Kim, Yunhi; Kwon, Soonki; Kim, Heeyeon; Park, Yunjee; Jeong, Hyein; Hwang, Jaeyoung; (77 pag.)US2017/77422; (2017); A1;,
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