In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 609-12-1 as follows. category: esters-buliding-blocks
A mixture of 4,4-difluorocyclohexanone (1.00 g, 7.46 mmol), ethyl 2-bromo-3-methylbutanoate (1.56 g, 7.46 mmol), zinc powder (561 mg, 8.57 mmol) in dioxane (20 mL) is stirred at 85 oC for 2 days. After the removal of solvent, the filtrate is concentrated in vacuo. The residual oil is purified by column chromatography on silica gel eluting with 0-30% ethyl acetate in hexane to give the titled compound (1.46 g, 74% yield) as a pale yellow oil.
According to the analysis of related databases, 609-12-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RAQUALIA PHARMA INC.; SHISHIDO, Yuji; OHMI, Masashi; ANDO, Kazuo; WO2015/136947; (2015); A1;,
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