Reference of 455-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 455-68-5 name is Methyl 3-fluorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A round bottom centrifuge tube containing catalyst 4 (6.7 mol percent based on the percent phosphorus determined by elemental analysis or as otherwise stated in the footnotes of the corresponding Tables) was equipped with a rubber septum and two magnetic stir bars for extra stirring efficiency. After flushing the tube with argon, it was charged via syringe with a higher ester (5 mmol) and MeOH (5 mL) for transesterifications. For amidations, the tube was similarly charged with an ester (2 mmol), amino alcohol (2 mmol), and THF (3 mL). The reaction mixture was vigorously stirred at room temperature (23-25 ¡ãC) and progress of the reaction was monitored by thin layer chromatography. Upon completion of the reaction, the reaction mixture was filtered through Whatman No. 1 filter paper and washed with 3 .x. 10 mL of THF. The combined organics were subjected to short-path silica gel chromatography (0-20percent ethyl acetate in hexanes v/v) to obtain an analytically pure product. In the case of amides, products were purified using a short-path silica gel column eluted with dichloromethane/methanol (95:5, v/v).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-fluorobenzoate, and friends who are interested can also refer to it.
Reference:
Article; Chintareddy, Venkat Reddy; Ho, Hung-An; Sadow, Aaron D.; Verkade, John G.; Tetrahedron Letters; vol. 52; 49; (2011); p. 6523 – 6529;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics