Adding a certain compound to certain chemical reactions, such as: 426-65-3, name is Ethyl Pentafluoropropionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 426-65-3, Computed Properties of C5H5F5O2
Compound 14 (1.2 g, 3.7 mmol) was dissolved in dry toluene (40 mL). Sodium hydride (0.18 g, 40% dispersion in oil) was added, and the mixture was stirred for 15 min at rt. Ethyl pentafluoropropionate (1.1 niL, 7.4 mmol) was added, and the mixture was stirred overnight at rt. Hydrochloric acid (IM, 40 mL) and dichloromethane were added, and the mixure was stirred for 10 min.The organic phase was separated, and the aqueus phase was extracted twice with dichloromethane. The combined organic phases were dried and concentrated. . Purification on silica gel (eluent 10% MeOH in CH2Cl2, v/v) yielded the title compound. 1H NMR (CDCl3): ? 7.71 (2H, d, J 7.9); 7.36 (IH, d, J 3.8); 7.30 (2H, d, J 7.9); 6.73 (IH, d, J 3.4); 6.06 (IH, s); 4.21 (2H, t, / 6.5); 3.12 (2H, m); 2.42 (3H, s).
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Reference:
Patent; WALLAC OY; WO2009/115644; (2009); A1;,
Ester – Wikipedia,
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