Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl (E)-3-Ethoxyacrylate
To a reactor was charged K3PO4 (4104 g granular, 19.3 moles), ethyl 3-amino-lH-pyrazole-4-carboxylate (2000 g, 12.9 moles), and DMF (18.8 kg) and the mixture was agitated. After 20 min, (?)-ethyl 3- ethoxyacrylate, (2230 g, 15.5 moles) was added and the mixture was heated to 110-115 C internal temperature (IT). After the reaction was judged to be complete based on consumption of starting material , heating was ceased. The mixture was allowed to stir and cool overnight. Aqueous hydrochloric acid (3 M, 13 L) was added over ~ 2 h. DI water (6 L) was added and the mixture was allowed to stir overnight. The mixture was filtered through polypropylene filter cloth (PPFC) and the residue was washed with water (3 x 5 vol, 3 x 10 L). The solid was placed in trays and oven dried under vacuum at 55 C for 3 days and then 45 C for 4 days to constant weight of (2553 g 95.6%).
The synthetic route of 5941-55-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZHAO, Qian; SPENCER, Stacey; JIANG, Yutong; HAAS, Julia; EARY, Charles Todd; (335 pag.)WO2018/81417; (2018); A2;,
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