Electric Literature of 87-24-1,Some common heterocyclic compound, 87-24-1, name is Ethyl 2-methylbenzoate, molecular formula is C10H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Ethyl 2-methylbenzoate (2.0 g, 12.2 mmol) was dissolved in 30 ml carbon tetrachloride. N-bromosuccinimide (2.17 g, 12.2 mmol) and benzoyl peroxide (80 mg, 0.33 mmol) were added and the mixture was heated at 80?C for 4 h. The mixture was allowed to cool and was stirred at room temperature overnight. The mixture was filtered and the solvent was evaporated to give 3.0 g (11.8 mmol, 97%) of the title compound as a yellow oil. Purity 96%. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.43 (t, J=7.23 Hz, 3 H), 4.42 (q, J=7.29 Hz, 2 H), 4.96 (s, 2 H), 7.38 (t, J=7.42 Hz, 1 H), 7.44 – 7.55 (m, 2 H), 7.97 (d, J=7.82 Hz, 1 H). HPLC/MS (9 min) retention time 6.30 min. LRMS: m/z 243 (M+1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-methylbenzoate, its application will become more common.
Reference:
Patent; Almirall, S.A.; EP2457900; (2012); A1;,
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