In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 91085-56-2, name is Ethyl 3,5-dichlorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Ethyl 3,5-dichlorobenzoate
Ethyl 3,5-dichlorobenzoate (8.4 g, 38.3 mmol) and sodiumhydride (1.1 g, 46.0 mmol) were dissolved in 100 mL THF underN2. To the mixture was added 13.2 mL ethyl propionate slowly atroom temperature and refluxed overnight. The solvent wasremoved under reduced pressure. The residue was extracted withethyl acetate, washed with water and brine and dried over Na2SO4.Flash column chromatography gave 9.7 g (92%) ethyl 3-(3,5-dichlorophenyl)-2-methyl-3-oxopropanoate 5 as orange solid. 1HNMR (400 MHz, DMSO-d6) d 7.97 (t, J = 3.3 Hz, 3H), 4.80 (q, J =6.9 Hz, 1H), 4.07 (q, J = 7.1 Hz, 2H), 1.31 (d, J = 6.9 Hz, 3H), 1.08(t, J = 7.1 Hz, 3H). MS (ESI, m/z): 274.0 [MH].
The synthetic route of 91085-56-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shu, Shuangjie; Dai, Antao; Wang, Jiang; Wang, Bin; Feng, Yang; Li, Jia; Cai, Xiaoqing; Yang, Dehua; Ma, Dakota; Wang, Ming-Wei; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1896 – 1908;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics