In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 140-39-6 as follows. Safety of p-Tolyl Acetate
Acetic acid(4-methyl) phenolate 50.0gSoluble in 500ml of carbon tetrachloride, add 4.0g BPO,Stirring at 50 C,Add 71.5g NBS ((4-methyl) phenolate (II) acetate and NBS in 3 batches,The molar ratio of BPO was 1:1.2:0.05), and the reaction was kept for 3 hours. Filtering,The filtrate was concentrated under reduced pressure.The orange-red oil was added dropwise to petroleum ether and stirred to disperse, and a solid precipitated. After suction filtration, the filtrate was washed with water.After drying, it was concentrated under reduced pressure to give (4-bromomethylene) phenyl ester (III), 68.3 g.Yield 89.2%,
According to the analysis of related databases, 140-39-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hubei Guangchen Pharmaceutical Co., Ltd.; Hubei University; Wuhan Institute of Technology; Wang Kai; Liu Dan; Zhao Yimei; Jiang Jun; Kuang Weidong; Zhou Ji; Wu Fengshou; Yang Fang; (7 pag.)CN108640834; (2018); A;,
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