Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10602-06-9, name is Methyl 3-ethynylbenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C10H8O2
General procedure: The alkyne (6 or 7, 1.24 mmol) was dissolved in tert-butanol(10 mL) and added to a water solution (10 ml) of N,N-Dimethyl-N-(3-azidopropyl)amine hydrochloride(226 mg, 1.37 mmol), copper (II) sulphate pentahydrate (31 mg, 10% mol) and sodium ascorbate (246 mg,1.24 mmol). The resulting mixture was stirred for 24 h, at r.t. The organic solvent was removed undervacuum and the residue was diluted with saturated NaHCO3 (10 mL) and extracted with DCM(3 x 20 mL). The combined organic phases were dried over Na2SO4 and the solvent was removedunder reduced pressure. The crude was purified by flash chromatography (CHCl3/MeOH 95:5).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Tassinari, Martina; Lena, Alberto; Butovskaya, Elena; Pirota, Valentina; Nadai, Matteo; Freccero, Mauro; Doria, Filippo; Richter, Sara N.; Molecules; vol. 23; 8; (2018);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics