Related Products of 23877-12-5, The chemical industry reduces the impact on the environment during synthesis 23877-12-5, name is tert-Butyl 2-bromo-2-methylpropanoate, I believe this compound will play a more active role in future production and life.
Reference Example 58 To a solution (50 ml) of (6-chloropyridin-3-yl)(2-hydroxy-4-methoxyphenyl)methanone (4.17 g) in N,N-dimethylformamide were added tert-butyl 2-bromo-2-methylpropanoate (17.6 g), potassium carbonate (10.9 g) and magnesium sulfate (5.70 g), and the mixture was stirred at 95C for 18 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography, eluted with ethyl acetate-hexane (1:7, v/v) to give tert-butyl 2-{2-[(6-chloropyridin-3-yl)carbonyl]-5-methoxyphenoxy}-2-methylpropanoate as a colorless oil. Recrystallization from ethyl acetate-hexane gave colorless prism crystals (3.49 g, 54%). melting point 128 – 129C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-2-methylpropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1911738; (2008); A1;,
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