Some common heterocyclic compound, 57486-68-7, name is Methyl 2-chlorophenylacetate, molecular formula is C9H9ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks
General procedure: 5.2.1 5,6-Dichloro-1,3-dihydro-3-(4-chlorophenyl)-indole-2-one (3) Sodium hydrate 60% (2.85 g, 71.2 mmol) at -10 C and under nitrogen atmosphere was suspended in N,N-dimethylformamide (DMF) (45 ml) before being added to a solution of 1,2-dichloro-4-fluoro-5-nitrobenzene (5 g, 23.8 mmol) and methyl-4-chlorophenyl acetate (4.4 g, 23.8 mmol). in DMF (70 ml) The mixture was stirred at -5 C for 2 h and then allowed to warm up to room temperature. After quenching with ice, an aqueous solution of 10% NH4Cl was added and the mixture was partitioned between EtOAc and water. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified using column chromatography on silica gel (hexane/EtOAc = 3/1) to give 1,2-dichloro-4-[2-(methy-l-4-chlorophenyl acetate)]-5-nitrobenzene (3.18 g, 36%) as a colourless oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57486-68-7, its application will become more common.
Reference:
Article; Puleo, Letizia; Marini, Pietro; Avallone, Roberta; Zanchet, Marco; Bandiera, Silvio; Baroni, Marco; Croci, Tiziano; Bioorganic and Medicinal Chemistry; vol. 20; 18; (2012); p. 5623 – 5636;,
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