Adding a certain compound to certain chemical reactions, such as: 57486-68-7, name is Methyl 2-chlorophenylacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57486-68-7, COA of Formula: C9H9ClO2
66.5 g (0.36 mol) of methyl o-chlorophenylacetate (III), 80 mL of tetrahydrofuran, and 8.9 g (0.37 mol) of sodium hydride were weighed.After stirring and dissolving, sodium hydride was completely dissolved, and then methyl 1-chlorocyclopropane-1-carboxylate 50 g (0.36 mol) was slowly added.Warm up to reflux, keep warm for 4h, gas phase tracking 1-chloro-1-carboxylic acid methyl ester-cyclopropane conversion rate of 99% or more, cooling to 20 ~ 25 C,The reaction solution was quenched by adding 60 mL of a 10% dilute hydrochloric acid solution, and 3.2 g (0.1 mol) of tetrabutyl bromide was added.The temperature is refluxed, the temperature is kept for 5 hours, the temperature is lowered to 20 to 25 C, and the organic phase is separated.The aqueous phase (50 mL x 2), extract the aqueous phase, and combine the organic phases.Desolventizing have to compound IV, as a pale yellow liquid 68g, 96% yield.
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Reference:
Patent; Anhui Jiuyi Agricultural Co., Ltd.; Shen Yunhe; Xiong Guoyin; Yu Zhenglian; Zhao Xiaojun; Zhou Quanquan; Fan Fuyun; (12 pag.)CN109369549; (2019); A;,
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