Related Products of 152849-72-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 152849-72-4, name is Methyl 5-bromo-2,4-dimethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.
Step 3: methyl 5-(1-(2-(difluoromethoxy)phenyl)piperidin-4-ylamino)-2,4-dimethylbenzoate 1-[2-(difluoromethoxy)phenyl]piperidin-4-amine (240 mg, 990 umol), methyl 5-bromo-2,4-dimethyl-benzoate (240 mg, 990 umol), Pd2(dba)3 (54 mg, 59 umol), BrettPhos (73 mg, 118 umol), Cs2CO3 (450 mg, 1 mmol) in toluene (5 mL) was stirred at 90 C. for 16 h. The mixture was filtered by celite, the filtrate was concentrated and was purified via silica gel chromatography eluting with PE/EA from 50/1 to 20/1 to obtain methyl 5-[[1-[2-(difluoromethoxy)phenyl]-4-piperidyl]amino]-2,4-dimethyl-benzoate (200 mg, 49.92%) as white solid. ESI-MS (EI+, m/z): 405 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis Methyl 5-bromo-2,4-dimethylbenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
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