Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40061-54-9, name is Ethyl 2-(2-chlorophenyl)acetate, A new synthetic method of this compound is introduced below., COA of Formula: C10H11ClO2
General procedure: Ethyl-2-arylacetate (2 mmol), aq.formaldehyde (1 mmol), aq.ammonia / aliphatic / aromatic amines (2 mmol) and a catalytic amount of piperidine and pyridine in abs. ethanol (250 mL) were refluxed for 4 hour. The course of the reaction was monitored by TLC, and after the disappearance of the starting materials, excess of alcohol is removed in vacuo and the residue extracted with benzene and washed with dil.HCl and then with water and dried. The dried benzene extract was purified by passing through a column of SiO2. The residue obtained on evaporation of the solvent, on crystallization (aq. EtOH) gave pure 3, 5-diarylpiperidin-2, 6-diones in appreciable yields (70-90percent).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Babu, Mariappan; Pitchumani, Kasi; Ramesh, Penugonda; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1263 – 1266;,
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