Adding a certain compound to certain chemical reactions, such as: 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756525-95-8, Formula: C11H23NO4
Preparation of (9H-fluoren-9-yl)methyl 2-((1-(3-(4-((2-(2-(3-(tert-butoxy)-3- oxopropoxy)ethoxy)ethyl)amino)piperidin-1-yl)-3-oxopropyl)-1H-indol-2-yl)methyl)-1,2- dimethylhydrazine-1-carboxylate (Fmoc-HIPS-PAPip(PEG2(CO2t-Bu))NH) (Figure 62) To a dried scintillation vial containing a magnetic stir bar was added Fmoc-HIPS- piperidinone (355 mg, 0.63 mmol), H2N-PEG2-COOtBu (175 mg, 0.76 mmol), 4 A molecular sieves (activated powder, 100 mg), and 1,2-dichloroethane (2.5 mL). The mixture was stirred for 1 h at room temperature. To the reaction mixture was added sodium triacetoxyborohydride (314 mg, 1.48 mmol). The mixture was stirred for 18 hours at room temperature. The resulting mixture was partitioned between EtOAc and saturated aqueous NaHCO3. The organic layer was washed with saturated aqueous NaHCO3 (2 x 5 mL), and brine (1 x 5 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure to yield the title compound as a yellow oil, which was carried forward without further characterization.
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Reference:
Patent; REDWOOD BIOSCIENCE, INC.; RABUKA, David; ALBERS, Aaron Edward; KUDIRKA, Romas Alvydas; GAROFALO, Albert W.; WO2015/81282; (2015); A1;,
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