1459-93-4, name is Dimethyl isophthalate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C10H10O4
Add 100 mL of tetrahydrofuran to the reaction flask.Then add 20.02 g (102.99 mmol) of dimethyl isophthalate and 0.50 g of EDTA-2Na to the inside.Nitrogen gas,Acetone dry ice cooled to -45 C,Control temperature does not exceed -45 C,257mL of 1.0M diisobutyl aluminum hydride toluene solution was added dropwise.After the addition, the reaction is incubated for 2 hours.Temperature control does not exceed 0 C drops 250mL potassium sodium tartrate saturated solution,filter,Liquid separation,The toluene phase is concentrated at 60-70C,Concentrate to 5% of the original volume,There are a lot of solids out,filter,Drying of methyl 3-formylbenzoate 14.20 g at 50CYield 84.02%,98.92% purity.
The synthetic route of 1459-93-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jinan Xuanhong Bio-pharmaceutical Co., Ltd.; Lou Yadong; Li Zhanjiang; (5 pag.)CN107162906; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics