In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106896-49-5, name is Methyl 4-amino-3-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 4-amino-3-bromobenzoate
General procedure: PCl5 (0.23 g, 1.1 mmol) was added to an ice-cold solution of compound 6 (0.30 g, 1 mmol) in ether (15 mL). The reaction mixture was stirred at room temperature for 2 h and then was concentrated under reduced pressure. The crude product was dissolved in THF (15 mL). The arylamine (1 mmol) and triethylamine (1.2 mmol) was added to the solution successively. The reaction mixture was stirred at room temperature for 2 h and then was then evaporated under reduced pressure. The residue was chromatographed on silica gel using ethyl acetate:petroleum ether (1:4). Pure fractions were collected and concentrated, giving the desired compound (7a-7o).
The synthetic route of 106896-49-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhan, Peng; Chen, Xuwang; Li, Xiao; Li, Dongyue; Tian, Ye; Chen, Wenwen; Pannecouque, Christophe; De Clercq, Erik; Liu, Xinyong; European Journal of Medicinal Chemistry; vol. 46; 10; (2011); p. 5039 – 5045;,
Ester – Wikipedia,
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