These common heterocyclic compound, 56741-34-5, name is Methyl 5-amino-2-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 56741-34-5
Dissolve intermediate 1b (0.36g, 1.26mmol) in acetone solution,The reactants 1c (214 mg, 1.26 mmol) and pyridine (0.254 ml, 3.16 mmol) were added sequentially.Then, the reaction solution was heated to reflux at 60 degrees for 2h, and the reaction was monitored by mass spectrometry.The reaction solution was spin-dried and dissolved in ethyl acetate, washed with 1M hydrochloric acid solution in turn,After washing with saturated sodium chloride and drying over anhydrous sodium sulfate, the crude intermediate 1d was obtained.1d crude product was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 5 / 1-2 / 1) to obtain 1d pure product (330mg, yield 62.5%),
The synthetic route of Methyl 5-amino-2-fluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fudan University; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; He Yulong; Wang Heyao; Li Yingxia; Dou Huixia; (68 pag.)CN110903224; (2020); A;,
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