Adding a certain compound to certain chemical reactions, such as: 25597-16-4, name is Ethyl 4,4,4-trifluorocrotonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25597-16-4, Quality Control of Ethyl 4,4,4-trifluorocrotonate
General procedure: To a solution of trifluorocrotonic acid (1.0 equiv) in DMF, was added the amino acid methyl ester hydrochloride (1.2 equiv), DIPEA (4.0 equiv), HBTU (1.2 equiv) and HOBt (1.2 equiv) in this order. The mixture was stirred overnight at room temperature under argon atmosphere. The solvent was evaporated under vacuum and the residue dissolved in ethyl acetate. The organic layer was washed with 10% citric acid aqueous solution (two times), water, 10% K2CO3aqueous solution (two times) and brine, dried over Na2SO4, filtrated and evaporated. The crude product was purified by column chromatography (EtOAc/cyclohexane: 3/7) to afford the corresponding alkene.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 4,4,4-trifluorocrotonate, and friends who are interested can also refer to it.
Reference:
Article; Schweitzer-Chaput, Bertrand; Keita, Massaba; Milcent, Thierry; Ongeri, Sandrine; Crousse, Benoit; Tetrahedron; vol. 68; 35; (2012); p. 7028 – 7034;,
Ester – Wikipedia,
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