Adding a certain compound to certain chemical reactions, such as: 57381-62-1, name is Methyl 2-bromo-4-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57381-62-1, name: Methyl 2-bromo-4-chlorobenzoate
In a 500 ml round-bottomed flask, 30 g (68.9 mmol) of the compound of formula C-1,17 g (68.2 mmol) of methyl 2-bromo-4-chlorobenzoate,1.6 g (1.38 mmol) of tetrakistriphenylphosphine palladium was added to 150 ml of tetrahydrofuran, mixed with 80 ml of an aqueous solution of 28.6 g (207 mmol) of potassium carbonate and refluxed for 24 hours. The impurities were removed using chloroform and water, and then anhydrous magnesium sulfate was added to remove moisture. The solution was filtered and then recrystallized using chloroform and ethanol to obtain 21.2 g (yield 65percent) of the formula C-2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-bromo-4-chlorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; LG Chemical Co.,Ltd; Kim, Su Yeon; Lee, Ho Yong; Jo, Sung Mi; (43 pag.)KR2016/2354; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics