Adding a certain compound to certain chemical reactions, such as: 927-68-4, name is 2-Bromoethyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-68-4, Recommanded Product: 2-Bromoethyl acetate
(R)-7-chloro-N-(piperidin-3 -yl)-4-(trifluoromethyl)benzo[b]thiophene-2-carboxamide (TFA salt, 95 mg, 0.20 mmol), Nal (50 mg, 0.33 mmol), K2C03 (180 mg, 1.30 mmole), 2- bromoethyl acetate (32 uL, 0.29 mmol) and DMF (2 mL) were added into a reaction flask, and stirred at room temperature overnight. The mixture was dissolved in ethyl acetate (20 mL) and water (5 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2x). The ethyl acetate layer was concentrated in vacuo and chromatographed on silica gel using hexanes and ethyl acetate to give title compound (50 mg, 0.11 mmol, 56%). ?H NMR (CD3OD, 400 MHz) 8.34 (s, 1H), 7.83 (dd, IN, J 0.4, 8.0 Hz), 7.68 (dd, 1H, J?0.4, 8.0 Hz), 4.50 (m, 2H), 4.38 (m, 1H), 3.73 (m, 1H), 3.56 (m, IH), 3.32 (m, 2H),3.02 (m, 2H), 2.14 (m, 5H), 2.00 (m, 2H), 1.79 (m, 2H). LCMS (ES) 449, 451 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromoethyl acetate, and friends who are interested can also refer to it.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; ICAHN SCHOOL OF MEDICINE AT MONT SINAI; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; KAMENECKA, Theodore, M.; KENNY, Paul; LINDSTROM, Jon, M.; WANG, Jingyi; JIN, Zhuang; DOEBELIN, Christelle; (95 pag.)WO2016/191366; (2016); A1;,
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