41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H9BrO2
To a suspension of sodium hydride (60% in oil, 192 mg, 4.80 mmol,) in DMF (11 mL) at 0 C was added methyl 2-(4-bromophenyl)acetate (0.35 mL, 2.2 mmol). The mixture was stirred for 15 minutes at 0 C and iodomethane (6.5 muL¡¤, 0.10 mmol) was added. The mixture was stirred for further 5 minutes at 0 C and at RT for 12 h, then quenched with 1 N aq. HCl (1 mL) and extracted with EtOAc (3 x 2 mL). The organic layer washed with H20 (3 x 2 mL) and brine (2 mL), dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by Si02gel chromatography (0% to 5% EtOAc/Hexanes) to give methyl 2-(4- bromophenyl)-2-methylpropanoate (550 mg, 98%); MS (ES+) CgHgBrC^ requires: 228, found: 229/231 [M+H]+.
The synthetic route of 41841-16-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JONES, Philip; DIFRANCESCO, Maria, Emilia; PETROCCHI, Alessia; MARSZALEK, Joe; LIU, Gang; KANG, Zhijun; CARROLL, Christopher, L.; MCAFOOS, Timothy; CZAKO, Barbara; WO2014/31928; (2014); A2;,
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