In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23877-12-5, name is tert-Butyl 2-bromo-2-methylpropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks
59.1) tert-butyl 2-methyl-2-(10H-phenothiazin-2-yloxy)propanoate: 1.93 g (3 eq.) of K2CO3 is added to a solution of 1 g (4.6 mmol) of intermediate 21.1 in 10 ml of DMF. The reaction mixture was heated to 60 C. before the addition of 1.73 ml (2 eq.) of tert-butyl 2-bromoisobutyrate. The mixture is then taken to 110 C. and stirring is maintained at this temperature for 6 hours. After returning to 20 C., the mixture is poured into 100 ml of water and the product is extracted using twice 100 ml of ethyl acetate. The organic solution is finally washed with 100 ml of salt water, dried over sodium sulphate, filtered and concentrated to dryness under vacuum. The evaporation residue is purified on a silica column, eluent: ethyl acetate/heptane (1/9). 450 mg of a pale pink solid is obtained with a yield of 28%. Melting point: 138-140 C.
The synthetic route of 23877-12-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Auvin, Serge; Chabrier De Lassauniere, Pierre-Etienne; US2005/222045; (2005); A1;,
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