Synthetic Route of 5335-05-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5335-05-7, name is Chloromethyl benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of compound 1d (120.0 mg, 0.306 mmo.) in DMF (3 mL) was added LiH (4.8 mg, 0.61 mmoi) at 0 0C. Then chloromethyi benzoate v (57.4 mg, 0.337 mmo., dissolved in 0.5 mL DIVtF) was added. The solution was stirred at 0 0C for 3 hours, and then was gradually warmed up to 25 CC and stirred at 25 0C for overnight. AcOH (0.042 mL, 0.733 mmo.) was added and the product was purified by C18 chromatography (CH3CNZH2O: 5% to 90%, with 0.1% HCO2H) to give compound 66 (110.5 mg, 68.6%),
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SCHERING CORPORATION; SHANKAR, Bandarpalle, B.; KIM, Seong, Heon; YU, Wensheng; TONG, Ling; WONG, Michael, K. C.; LAVEY, Brian J.; KOZLOWSKI, Joseph, A.; CHEN, Lei; RIZVI, Razia, K.; KOSINSKI, Aneta, Maria; YANG, De-Yi; ZHOU, Guowei; ROSNER, Kristen, E.; FIRE, Luke; RICHARD, Judson, E.; LI, Dansu; WO2010/36638; (2010); A2;,
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