Adding a certain compound to certain chemical reactions, such as: 5202-89-1, name is Methyl 2-amino-5-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5202-89-1, Application In Synthesis of Methyl 2-amino-5-chlorobenzoate
Water was added (5 ml) to a stirred suspension of 2-amino-5-chloro methyl benzoate (0.33 g, 1.77 mmol) in concentrated hydrochloric acid (1.1 ml) at [0C.] A solution of sodium nitrite (0.12 g, 1.77 [MMOL)] in water (1 [ML)] was added dropwise and the solution stirred until complete dissolution. The diazonium salt was brought to Ph. 6.0. with saturated sodium bicarbonate. In a separate flask, a solution of [CUS04.] 5H20 (0.53 g, 2.12 [MMOL)] in water (2 [ML)] was added dropwise to a stirred solution of potassium cyanide (0.53 g, 8.13 [MMOL)] in water (2 [ML)] at [0C.] Toluene (3 [ML)] was added and the resultant brown mixture stirred and heated to [60C.] The previously prepared diazonium solution was added to the Cu [(I)] CN at [60C] over a period of 30 mins. The reaction mixture was heated to [70C] for an additional 1 hour, then cooled to room temperature. The brown mixture was diluted with ethyl acetate (70 [MI),] filtered through a pad of [CELITE,] washed with ethyl acetate (3 x 20 ml), the combined organics washed with brine (50 [ML),] dried over magnesium sulfate, filtered and the solvent removed by evaporation under reduced pressure to give a dark orange solid. The solid was dissolved in minimum [DICHLOROMETHANE] was purified by flash chromatography on silica gel eluting with a solvent gradient of heptane: ethyl acetate (3: 1) to give the title compound (0.23 g, 65 %) as an off-white solid. H-NMR (400 MHz, [CDCI3)] : [9] = 4.0 (s, 3H), 7.62 (dd, [1H),] 7.72 (dd, [1H),] 8.12 (d, 1H). LRMS (Electrospray) : m/z [M + [H] + 218.] Microanalysis : Found: C, 55.16 ; H, 3.09 ; N, 7. 08. [C9H6N02CI] requires C, 55.26 ; H, 3.09 ; N, 7.16%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-chlorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/14357; (2004); A2;,
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