4131-74-2, name is Dimethyl 3,3-Thiodipropionate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Dimethyl 3,3-Thiodipropionate
2.7098 g of NaH (60%) was added to 250 ml of dry three-necked flask,40 ml of anhydrous tetrahydrofuran (THF) was added,Stirred at room temperature for 10 min,A solution of dimethyl 3,3′-thiodipropionate (10.1015 g)In THF (30 ml) was added and heated to reflux,About 1h drops finished,After adding 10mlTHF rinse the dropping funnel,Continue to return after 1h,The reaction was stopped and allowed to cool to room temperature.The reaction solution was adjusted to a pH of 6 to 7 with 2% dilute hydrochloric acid and then extracted with dichloromethane (30 ml * 3)The layers were washed with saturated sodium chloride solution and the organic layer was collected and washed with sufficient anhydrous sodium sulfate and filtered. The filtrate was filteredThe solvent was removed by evaporation to give 7.5639 g of a yellow oily liquid,4-oxo-tetrahydro-2H-thiopyran-3-carboxylic acid methyl ester (II)Yield 88.7%.
The synthetic route of 4131-74-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Sun Chengyu; Tang Qidong; Chen Chen; Lei Fei; Wu Chunjiang; Tu Yuanbiao; Ouyang Yiqiang; (42 pag.)CN105153190; (2017); B;,
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