In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4224-69-5 as follows. Recommanded Product: Methyl 2-(bromomethyl)acrylate
General procedure: Into a round bottom flask charged with a magnetic stirbar was added 1.0 equiv. allylic bromide. This material was suspended in deionized water to produce a 1.0 M suspension. 1.5 volumetric equiv. of THF (w/respect to H2O) were then added with vigorous stirring, followed by 1.5 equiv. aldehyde and 1.1 equiv. indium powder. The reaction mixture was stirred for 12 hours, then was partitioned between EtOAc and deionized water. After separating the organic layer, the residual product was extracted with multiple portions (as necessary) of ethyl acetate. The combined organic layers was washed with brine, dried with Na2SO4, filtered, concentrated, and purified via column chromatography.
According to the analysis of related databases, 4224-69-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Nicponski, Daniel R.; Tetrahedron Letters; vol. 55; 13; (2014); p. 2075 – 2077;,
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