Synthetic Route of 15568-85-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15568-85-1 name is 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 5-(methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (7.0g,37.7mmol) and 2-methoxypyridin-4-amine (3.6g, 29.0mmol) disolved in i-PrOH(50mL) was refluxed at 100C for 1 hour, then the reaction solution was cooled toroom temperature to give crystalline solid which was filtered, washed with i-PrOHand diethyl ether to affor the compound 11 as a yellow crystalline solid (5.2g, 65%).1H NMR (400 MHz, Chloroform-d) delta 11.08 (d, J = 14.0 Hz, 1H), 8.66 (d, J = 14.0Hz, 1H), 8.17 (d, J = 5.7 Hz, 1H), 6.75 (dd, J = 5.7, 1.8 Hz, 1H), 6.55 (d, J = 1.8 Hz,1H), 3.95 (s, 3H), 1.75 (s, 6H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione, and friends who are interested can also refer to it.
Reference:
Article; Cheng, Yu; Shen, Jian; Peng, Run-Ze; Wang, Gui-Feng; Zuo, Jian-Ping; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry Letters; vol. 26; 12; (2016); p. 2900 – 2906;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics