Reference of 28868-76-0, These common heterocyclic compound, 28868-76-0, name is Dimethyl 2-chloromalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
b) 18.2 g of 2-chloro-5-methoxyphenol were dissolved in 150 ml of dry methanol. 9.3 g of MeONa were added, followed by 25 g of dimethyl chloromalonate. The reaction mixture was stirred at 50 C. for 2 hours. After distillation of the solvent the residue was partitioned between toluene and H2 O in a separating funnel and washed neutral. After crystallization in ethanol there was obtained (2-chloro-5-methoxy)phenoxy-dimethylmalonate, white crystals with m.p. 68-69 C.
Statistics shows that Dimethyl 2-chloromalonate is playing an increasingly important role. we look forward to future research findings about 28868-76-0.
Reference:
Patent; Hoffmann-La Roche Inc.; US5837708; (1998); A;,
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