Electric Literature of 884497-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 14 (100 g, 591 mmol), compound 15 (107.68 g, 591 mmol) and dioxane (1000 ml) were added into a first reactor, then PPTS (60.82 g, 118.2 mmol) and MgSO4 (355.77 g, 2.96 mol) were added into the first reactor, then the first reactor was heated to reflux and stirred for 3 hours, cooled down to 50 C. NaBH4 (89.46 g, 2.36 mol) was added into the mixture and heated to 80 C., the first reactor was then stirred for 3 hours. After the reaction, the first reactor was cooled down to room temperature, methanol was added into the first reactor and white solid was filtered. The filtrate was concentrated and extracted by ethyl acetate, then washed with saturated NaHCO3 aqueous solution and sodium chloride aqueous solution. The organic phase was dehydrated with anhydrous sodium sulfate, filtered and concentrated to obtain crude product. The crude product was purified by column chromatography to give compound 16 (100 g, yield 53.3%). (0061)LC-MS (ESI) m/z: 318 (M+H)+.
The synthetic route of Methyl 3-amino-5-fluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Xu, Yong; Yohi, Peter W; Xu, Michael; Cruise, Douglas; (12 pag.)US9708319; (2017); B1;,
Ester – Wikipedia,
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