41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 41841-16-1
A solution of methyl 2-(4-bromophenyl)acetate (6g, 30mmol) in tetrahydrofuran (67.2ml, 0.39/W) was added 1 M potassium t-butoxide in tetrahydrofuran (57.6ml, 57.6mmol). Reaction mixture was cooled to 00C and methyl iodide (3.59ml, 57.6mmol) was added drop wise. After addition was complete, reaction was slowly warmed up to room temperature and stirred for 16 hours. Reaction mixture was then carefully quenched with 1 M hydrochloric acid and concentrated. Reaction was diluted with water and extracted with ethyl acetate. Pooled organics were washed with water and brine and then dried over sodium sulfate, filtered and concentrated to give a crude dark oil. Crude product purified on silica gel eluting with 0%-5% ethyl acetate in heptane to give methyl 2-(4-bromophenyl)-2-methylpropanoate (1 D-1 ) (6.44g, 92%) as a yellow oil 1 H NMR (400 MHz, CHLOROFORM-d) d ppm 1.54 (s, 6 H) 3.63 (s, 3 H) 7.19 (d, J=8.78 Hz, 2 H) 7.43 (d, J=8.98 Hz, 2 H)MS(LC-MS) 371.2 (M+1 )
The synthetic route of 41841-16-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John; WO2010/86820; (2010); A1;,
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