Reference of 927-68-4,Some common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 7-1 (200 mg, 0.9 mmol) And sodium hydride (54mg, 1.35mmol) dissolved in 3ml DMF and stirred for 30 minutes, Add 2-bromoethyl acetate (165 mg, 0.99 mmol) in 2 ml of DMF, Stir overnight at room temperature. On the following day, after the reaction was detected by TLC, water was added for extraction. It was washed with saturated brine and dried over anhydrous sodium sulfate. Suction filtration, the filtrate was concentrated under reduced pressure, the crude product was separated by column chromatography, 172 mg of a colorless oil was obtained in a yield of 61%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromoethyl acetate, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Meng Linghua; Ding Jian; Chen Shulun; Ding Chunyong; Guo Wei; (26 pag.)CN110143955; (2019); A;,
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